NON-RECESSIVE BT TOXIN RESISTANCE CONFERRED BY AN INTRACELLULAR CADHERIN MUTATION IN FIELD-SELECTED POPULATIONS OF COTTON BOLLWORM.

Non-recessive Bt toxin resistance conferred by an intracellular cadherin mutation in field-selected populations of cotton bollworm.

Transgenic crops producing Bacillus thuringiensis (Bt) toxins have been planted widely to control insect pests, yet evolution of resistance by the pests can reduce the benefits of this approach.Recessive mutations in the extracellular domain of toxin-binding cadherin proteins that confer resistance to Bt toxin Cry1Ac by disrupting toxin binding hav

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Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

The blood system is supported by hematopoietic stem and progenitor cells (HSPCs) found in a specialized microenvironment called the niche.Many different niche Carriers cell types support HSPCs, however how they interact and their ultrastructure has been difficult to define.Here, we show that single endogenous HSPCs can be tracked by light microscop

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The Importance of Integrating Clinical Relevance and Statistical Significance in the Assessment of Quality of Care--Illustrated Using the Swedish Stroke Register.

When profiling hospital performance, quality inicators are commonly evaluated through hospital-specific adjusted means with confidence intervals.When identifying deviations from a norm, large hospitals can have statistically significant results even for clinically irrelevant deviations while important deviations in small hospitals can remain undisc

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